Kathryn Strange PhD Student in the Translational Immunotherapy Research team working in the ANRI laboratory

Donating for Medical Research and Treatments

At Anthony Nolan, our years of experience facilitating stem cell donations mean we have the expertise and infrastructure to support the development of innovative treatments.

What’s on this page?

What does ‘donating for medical research and treatments’ mean?

Medical research aims to improve our understanding of a disease or health condition and can also help discover new treatments. It can range from early lab-based studies through to clinical trials. This research needs donated cells from healthy donors, like you, to make sure that when treatments reach patients, they are safe and effective.

Cell and gene therapies are an exciting part of medical research and are evolving quickly. They have the potential to offer more effective and personalised treatments for diseases which historically have been difficult, or were thought to be impossible, to treat. Donated cells may be used to help create these new treatments.

These treatments could not only save more lives but help to improve patients’ quality of life as well. This means we are now contacting donors to offer them the opportunity to donate their cells for medical research and the development of treatments.

Who are you working with?

We will be working with leading medical researchers to support their work and provide opportunities for our incredible donors to help. This will involve working with lots of different types of organisations, including hospitals, academic institutions and pharmaceutical companies.

To ensure that Anthony Nolan only supports ethically sound and patient-benefiting medical research, an independent review board will assess each new medical research application before agreeing to collaborate.

The difference you could make

We only offer the option to donate either lymphocytes or peripheral blood stem cells (PBSC) to medical research. By donating your cells, you have the opportunity to impact even more lives. One donation for a medical research project could unlock new discoveries and help shape the future of treatments.

In medical research, PBSC and lymphocytes are used to understand how the human immune system works, and what happens when it goes wrong. This makes them a valuable source of information about how the immune system develops.

Using this knowledge, medical researchers can develop new innovative treatments for life-threatening conditions which were previously difficult to treat. To find out more about the specific project you have been invited to take part in, take a look at the project information sheet you’ve been sent and ask your Coordinator if you have any questions

Your cells can also contribute directly to new cell therapies that are being investigated in clinical trials, directly benefiting patients immediately and contributing to work to get new therapies approved for more patients in future.

You can find out more about the types of research projects that your cells could contribute to here!

To find out more about the specific project you have been invited to take part in, take a look at the project information sheet you’ve been sent and ask your Coordinator if you have any questions. 

Your decision

Whether you choose to donate is completely up to you. You can read about the important things to consider when donating here.

Discuss the idea of donating with your friends and family before agreeing to the next stage. You can change your mind at any time, and we want to make sure you’re well informed before you decide.

We’re all very lucky to have amazing medical science in the UK should we ever need it, so this was a chance for me in a small way to give back.

George

Interested in donating for medical research and treatments?

We are only asking people to donate for medical research who are already on our stem cell register. If you are a donor on our registry and are interested in donating for medical research please email us to let us know: researchdonors@anthonynolan.org.

We don’t have a separate register for medical research donors. Individuals who are willing to donate cells for a patient in need and eligible to join the Anthony Nolan register can join online at Join the stem cell register.

Being on the Medical Research Donor Panel

What are the first steps?

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Donors who are willing to donate their cells to medical research will need to be enrolled on to the Medical Research Donor Panel. To be enrolled you will need complete a pre-screening questionnaire. The questionnaire covers your general health as well as your availability and preferences for the use of your cells.

Once you have completed this and it’s been cleared, you will be enrolled on to the Medical Research Donor Panel.

What happens when I'm on the Medical Research Donor Panel?

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Once you are on Medical Research Donor Panel, you can expect to hear from Anthony Nolan every time a medical researcher requests a donation for their project. We will contact you via email with the date, time, type of donation, and a bit of background on the research project to see if you are available and interested to donate. It's your choice if you want to donate to the request. Please feel free to reach out to the Anthony Nolan Coordinators if you have any questions about the request.

For each request we like to find two donors: a primary and a secondary - just in case one donor can't donate for any reason.

If you are available and interested, let the Anthony Nolan Coordinators know by completing the survey linked in the invitation email. They will tell you if you are the primary donor or the secondary donor, and walk you through the next steps in the donation process.

Going on to donate

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Before you go on to donate, your Anthony Nolan Coordinator will arrange a medical examination at a specialist hospital. The medical is a series of checks and tests to ensure you are able to donate, you can read about what this involves here.

If you have already had a medical, you may need to repeat some tests to ensure you are still fit to donate. Your Anthony Nolan Coordinator will arrange this with you.

If the primary donor is cleared they will go on to donate for the request. The secondary donor remains on the Medical Research Donor Panel and will be asked first as a priority for any future donation requests.

But if the primary donor is not cleared, the secondary donor will go forward for the donation instead. Your Anthony Nolan Coordinator will lead you through each and every step up until your donation.

Your questions

Can I find out the outcome of the medical research?

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Please ask if you would like to find out more about the medical research project you’re involved in. We will try our best to give you as much information as we can; however it is often not possible for us to provide information about the outcomes of research. This can be for confidentiality reasons, or simply because research takes many years to be published and shared with the public.

Following our social media channels is a great way of staying up-to-date with the latest research advances and what they mean for patients.

Will I still be able to donate to a patient?

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Of course! You will not be taken off the register and will still be available to be selected as a match for a transplant patient. If you are chosen as a preferred donor for a transplant patient, we can cancel your donation for medical research at any time as the donation to a transplant patient takes priority.

You can also donate more than once, so taking part in a medical research project will not stop you from being chosen as a matching transplant donor in the future. People who donate via PBSC or bone marrow can do so for a maximum of two transplant patients or four times in total. Donating for medical research will count as one transplant patient.

Will I be getting paid to donate my cells for medical research?

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You will not receive any payment for donating your cells for medical research, as this is illegal in the UK and also comes with ethical and welfare risks (read more here). However, any expenses you incur at all for the donation - like travel, accommodation or loss of earnings - will be fully reimbursed.

Will my cells be used in animal testing?

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Anthony Nolan does not conduct animal research in our laboratories. However occasionally, when pioneering medical research requires it and there is no alternative available, we work with other organisations where animal research is used to develop and improve treatments.

Cancer survival rates have doubled over the past 40 years. This achievement would not have been possible without animal research, which has resulted in the discovery, development and testing of lifesaving treatments. As a member of the Association of Medical Research Charities (AMRC) we support the principle of using animals in research when it is necessary to advance understanding of health and disease and to develop new treatments.

In the UK, there are very strict regulations governing the use of animals in research to ensure that animals are treated ethically and that any pain or distress is minimised. The use of animals in scientific procedures within the UK is regulated by the Animals (Scientific Procedures) Act 1986 (ASPA), administered and enforced by the Home Office’s Animals in Science Regulation Unit. We ensure that organisations we work with have a clear and transparent policy around animal research and that they conform to the 3Rs – Replace, Refine, Reduce – which help guide researchers to only use animals when absolutely necessary.

During the consent process, you will have the chance to opt out of donating for research involving animals. This limits the pool of projects for which you may be invited to donate.

Will the researchers get any of my personal information?

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We will never share your name, address or contact details with the researchers. They may ask for your age and gender, and sometimes your tissue type, health status, ethnicity, and/or infectious disease profile, but this will be anonymised .

Does Anthony Nolan make money from stem cell donations?

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Anthony Nolan receives payment for the service it delivers providing donated cells to academic researchers and companies developing new treatments to help patients. Anthony Nolan is a non-profit organisation. This vital income is reinvested into delivering on Anthony Nolan’s charitable aims – saving and improving even more lives, supporting the patient of today through patient information and services, and supporting the patient of the future through delivering and supporting ground-breaking medical research. Anthony Nolan does not charge its own researchers for this service.

Emma MacKay, donation her stem cells
Emma

Lots of people think that donating is going to be painful, so every time I’ve spoken to someone about it I’ve explained how easy it is.

Emma